postoperative pulmonary complications after liver transplantation
Conditions
Interventions
Normal saline:Saline group receives a continuous infusion of 0.3 mg/kg/h until the end of surgery after anesthesia induction.
Esketamine:Esketamine group receives a continuous infusion of 0.3 mg/kg/h until the end of surgery after anesthesia induction.
Sponsors
The First Affiliated Hospital of Guangxi Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1: Age 18-70 years, BMI < 28 kg/m^2; 2: ASA ? or ?; 3: undergoing DBD liver transplantation with general anesthesia
Exclusion criteria
Exclusion criteria: 1: A contraindication or allergy to esketamine 2: Preoperative comorbid respiratory diseases (acute respiratory infections, chronic obstructive pulmonary disease), bronchopleural/oesophageal fistula,physema and pneumothorax 3: Preoperative comorbidities, including heart, lung, and kidney failure, as well as brain disease; 4: Merge autoimmune diseases; 5: The duration of preoperative smoking cessation is less than 2 months, and the bedridden time is greater than 2 months; 6: Preoperative use of ventilator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of pulmonary complications within 7 days after surgery;Postoperative liver and kidney functio; | — |
Secondary
| Measure | Time frame |
|---|---|
| inflammatory factors;Intraoperative opioid consumption;Intraoperative use of vasoactive drug dosage;Postoperative intubation time in the ICU;Postoperative ICU stay duration;Total postoperative hospital stay; | — |
Countries
China
Contacts
Public ContactXiaolian Nong
The First Affiliated Hospital of Guangxi Medical University
Outcome results
None listed