Ovarian cancer
Conditions
Interventions
Intervention grop:Impact@ immunonutrition intervention
Sponsors
Zhejiang Cancer Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. aged over 18 years and under 75 years; 2. patients diagnosed with ovarian cancer confirmed by histological or cytological diagnosis, who are intended to be treated by primary debulking surgery; 3. with NRS-2002 score >= 3, ECOG score 35.0 g/L or albumin < 30 g/L but can be increased to 35.0 g/L after 7-14 days of nutritional intervention with isolated whey protein components; 4. lifetime expectancy greater than 6 months; 5. can tolerate enteral and parenteral nutritional therapy; 6. patients are able to give informed consent, agree to participate in the study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. patients changing their programme to NACT; 2. patients who are not suitable for body composition analyses, e.g., those in whom the presence of metallic substances in the body, such as internal fixators, pacemakers, etc., may affect the results; 3. any sign of severe or uncontrolled systemic disease that, in the opinion of the investigator, may significantly affect the patient's risk/benefit balance, including uncontrolled hypertension, hepatitis B, hepatitis C, and human immunodeficiency virus; 4. preoperative albumin <35.0 g/L and remains below 35.0 g/L after 7-14 days of nutritional intervention with isolated whey protein components; 5. patients who had primary tumour at other sites within 3 years; 6. female patients who are pregnant or breast-feeding; 7. according to the investigator, patients who were not suitable for inclusion or had poor adherence to the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Post-operative complication rate within 30 days; | — |
Secondary
| Measure | Time frame |
|---|---|
| Length of hospitalisation;Rate of unplanned secondary operations;30-day unplanned re-admission rate;Time to first chemotherapy;Nutritional status of patients; | — |
Countries
China
Contacts
Public Contacttao zhu; yi lu
Zhejiang Cancer Hospital
Outcome results
None listed