Non-Small Cell Lung Cancer
Conditions
Interventions
Conventional Group:After the patient enters the operating room, anesthesia induction and maintenance are performed using intravenous anesthesia. Following anesthesia induction, a double-lumen endotrac
Denitrogenation and Pure Oxygen Re-expansion Group:After the patient enters the operating room, anesthesia induction and maintenance are performed using intravenous anesthesia. Following anesthesia in
Sponsors
Department of Thoracic Surgery, Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.ASA classification I-III; 2.Age >=18 years, no gender restrictions; 3.Adult patients undergoing thoracoscopic lobectomy; 4.Consent to participate in this study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Pulmonary function FEV1 < 70% of predicted value; 2.Percutaneous arterial oxygen saturation (SpO2) < 90% before opening the pleura; 3.Preoperative CT indicating anatomical variations of the trachea, main airway tumors, pulmonary bullae, or atelectasis; 4.Preoperative localization and puncture of pulmonary nodules; 5.History of previous thoracic surgery; 6.Severe arrhythmia; 7.Use of angiotensin-converting enzyme inhibitors (ACEI); 8.Significant intraoperative pleural adhesions (Note: Adhesion area exceeding a single lung lobe or cumulative adhesion area reaching 30% or more of the lung surface area); 9.Patients who received neoadjuvant therapy before surgery; 10.History of tuberculosis or tuberculous pleuritis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| lung collapse scale,LCS; | — |
Secondary
| Measure | Time frame |
|---|---|
| HR;MAP;SpO2;PaO2;PaCO2;Duration of bilateral lung ventilation;Duration of single-lung ventilation;Hypoxemia during One-Lung Ventilation; Hypotension;Assessment of Lung Re-expansion at 1 Month Postoperative (Chest CT):;Duration of Surgery ;Bleeding;Postoperative Drainage Volume;Intubation Duration;Whether to Transfer to the ICU ; Postoperative Complication Rate; Length of Hospital Stay;Hospitalization Cost; | — |
Countries
China
Contacts
Public ContactHao Zhang
Affiliated Hospital of Xuzhou Medical University
Outcome results
None listed