Central precocious puberty in girls
Conditions
Interventions
Gold Standard:At present, CPP is widely treated with gonadotropin-releasing hormone analogues at home and abroad. GnRH provocation test is the gold standard for diagnosis. Detection method (LH peak va
Index test:The stimulating effect of GnRHa is dozens of times stronger than that of natural GnRH, and the peak value appears in 60~120 min, which is widely used in the diagnosis of CPP, but it is sugg
Sponsors
children's hospital of fudan university
Eligibility
Sex/Gender
Female
Age
6 Years to 8 Years
Inclusion criteria
Inclusion criteria: 1. Before the age of 8, breast development occurred, and the time of breast development was less than 3 months. 2. Age 6~8 years old. 3. According to Tanner's staging standard, the breast development was B2 or B3. 4. No menarche; 5. Accepting triptorelin provocation test; 6. Signed informed consent form;
Exclusion criteria
Exclusion criteria: 1. The organic diseases that can affect the function of HPGA include pituitary tumors and ovarian cysts. 2. Before seeing a doctor, take drugs that may affect HPGA, such as taking traditional Chinese medicine within one month. 3. Obesity caused by endocrine and genetic metabolic diseases; 4. With chronic diseases of liver, kidney, thyroid or other systems. 5. The BMI is lower than the 5th percentile of BMI of girls of the same age; 6. The researcher believes that there are any other factors that are not suitable for selection or affect the participation and completion of this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Triptorelin provocation test LH peak >=8 IU/L Triptorelin provocation test is the best cut-off value, specificity and sensitivity for diagnosing CPP girls' LH peak.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Safety of Trip Stimulation Test in Diagnosing CPP Girls; | — |
Countries
China
Contacts
Public ContactLuo Feihong
children's hospital of fudan university
Outcome results
None listed