Knee osteoarthritis
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1 Diagnosed with knee osteoarthritis and scheduled for unilateral TKA, with no plan for contralateral TKA within the 3-month follow-up period. 2 American Society of Anesthesiologists (ASA) score of 1-3. 3 Age 18-80 years, both genders. 4 Willing and able to express consent to participate in the study. 5 Deemed by the investigator as willing and able to comply with study protocols
Exclusion criteria
Exclusion criteria: 1 Allergic to amide drugs 2 Have severe underlying diseases, including refractory hypertension, disseminated cancer, acute cerebral infarction, sequelae of cerebral hemorrhage, acute myocardial infarction, severe mental illnesses, and other comorbidities 3 Unable to tolerate general intravenous anesthesia 4 Obvious nerve damage found on the surgical side 5 Varus or valgus deformity of the knee joint on the surgical side is greater than or equal to 15 degrees 6 Intraoperative pathology suggests infection or other conditions that make joint replacement inappropriate 7 The patient has participated in other clinical research projects within the past 6 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The cumulative pain assessed within 72 hours postoperatively using a 0-10 Numeric Rating Scale (NRS), summarized by the area under the curve; | — |
Secondary
| Measure | Time frame |
|---|---|
| the number and proportion of patients meeting discharge criteria within 24 hours postoperatively, cumulative opioid consumption within 4 hours postoperatively;the number and proportion of patients meeting discharge criteria within 24 hours postoperatively, cumulative opioid consumption within 8 hours postoperatively;the number and proportion of patients meeting discharge criteria within 24 hours postoperatively, cumulative opioid consumption within 12 hours postoperatively;the number and proportion of patients meeting discharge criteria within 24 hours postoperatively, cumulative opioid consumption within 16 hours postoperatively;the number and proportion of patients meeting discharge criteria within 24 hours postoperatively, cumulative opioid consumption within 20 hours postoperatively;the number and proportion of patients meeting discharge criteria within 24 hours postoperatively, cumulative opioid consumption within 24 hours postoperatively; | — |
Countries
CHINA
Contacts
The first hospital of Jilin University