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Application of dexmedetomidine hydrochloride nasal spray in oral implant surgery ——a multicenter prospective randomized controlled study

Application of dexmedetomidine hydrochloride nasal spray in oral implant surgery ——a multicenter prospective randomized controlled study

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500097744
Enrollment
Unknown
Registered
2025-02-25
Start date
2025-02-25
Completion date
Unknown
Last updated
2025-03-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dental anxiety

Interventions

Routine medical group:no
Low-dose intervention group:Dexmedetomidine hydrochloride nasal spray
High-dose intervention group:Dexmedetomidine hydrochloride nasal spray

Sponsors

Stomatological Hospital of Chongqing Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1. 18 years = age <70 years; 2. Patient ASA scores I to II; 3. Low risk of airway obstruction (Mallampati score I to II); 4. Dental phobia patients (MDAS =12 points); 5. Patients with implant surgery time <90min; 6. Willing to participate in this study and to sign the informed consent form.

Exclusion criteria

Exclusion criteria: 1. Preoperative patients showed active cooperation, without anxiety or blood pressure> 180 / 100mmHg; 2. Patients not suitable for nasal spray administration, such as nasal congestion, severe rhinitis, nasal deformity, etc; 3. History of cerebral palsy, autism or other mental illness, using psychiatric medication; 4. Recent alcohol consumption, taking other drugs, especially selective a 2-adrenoceptor agonists or antagonists, sedative hypnotics, amphotericin B, opioid analgesics; 5. Patients with a known past medical history of myocardial infarction, unstable angina pectoris, severe arrhythmia, and cardiac insufficiency; 6. Known allergy to drugs or other ingredients in the drug; 7. Can not cooperate with the study for any reason;

Design outcomes

Primary

MeasureTime frame
Dental Anxiety Score;Adverse reactions;Sedation Score;Visual Analogue Score;Discharge Score;Basic vital signs;

Secondary

MeasureTime frame
Patient Satisfaction Survey;Doctor Satisfaction Survey;Basic patient information;

Countries

China

Contacts

Public ContactYujia Wu

Stomatological Hospital of Chongqing Medical University

500324@hospital.cqmu.edu.cn+86 23 88860192

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026