Hepatic encephalopathy
Conditions
Interventions
fecal microbiota transplantation + standard treatment group (FMT group):After standard treatment of lactulose + aspartate ornithine ± rifaximin, after the condition stabilizes for 5-7 days, fecal micr
standard treatment group (STgroup):Lactulose 30ml once a day oral + aspartate ornithine ± rifaximin standard treatment) After the condition stabilized for 5-7 days, 40ml saline enema was given once a
Sponsors
Beijing Ditan Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.18-75 years old; 2.At least two hepatic encephalopathy attacks within half a year; 3.In the recurrence of hepatic encephalopathy at the time of enrollment; 4.Good adherence to hepatic encephalopathy drugs (patients can take lactulose and rifaximin); 5.I or my guardian understand and sign written informed consent and voluntarily join this study; 6.Women of childbearing age must agree to use effective contraceptive measures during the study period, 10 days before the study and 30 days after the study; 7.Women of childbearing age have a negative pregnancy test.
Exclusion criteria
Exclusion criteria: 1.MELD score >17; 2. WBC count <1×10^9/L or platelet count <50×10^9/L; 3.Receive blood purification treatment; 4.Known untreated malignant tumors; 5.Chronic inherent gastrointestinal disease (ulcerative colon inflammation, Crohn's disease or microscopic colitis, eosinophilic gastroenteritis and celiac disease) or intestinal obstruction; 6.Major gastrointestinal or abdominal surgery within three months; 7.Continuous use of antibiotics (except rifaximin); 8.Allergic constitution; 9.Researchers believe that other conditions are not suitable for treatment with fecal bacteria transplantation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The ratio of patients with hepatic encephalopathy above level 2 within 3 months; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hepatic encephalopathy psychometric score;The incidence of events in decompensated period of cirrhosis;Readmission rate;Changes in intestinal flora and characteristic flora; | — |
Countries
China
Contacts
Public ContactYang Song
Beijing Ditan Hospital of Capital Medical University
Outcome results
None listed