Postoperative pain
Conditions
Interventions
Low-dose group:Nalbuphine bolus 0.1mg/kg, maintenance 50µg/kg/h
Medium-dose group:Nalbuphine bolus 0.1mg/kg, maintenance 60µg/kg/h
High-dose group:Nalbuphine bolus 0.1mg/kg, maintenance 70µg/kg/h
Sponsors
The First Affiliated Hospital of Shantou University Medical College
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age above 18 or below 65 years old; 2. Critical Pain Observation Tool (CPOT) score>=3; 3. Intensive Care Unit (ICU) stay for 48 hours or longer.
Exclusion criteria
Exclusion criteria: 1. Acute Physiologic Chronic Health Evaluation II ( APACHE II) score >=23; 2. Acute Gastrointestinal Injury (AGI Grade) >=3; 3. Severe hepatic dyfunction (Child-Pugh class C); 4. Pregnant women, children (= 65 years old); 5. History of continous treatment with hypnotics or analgesics for more than 3 months; 6. Allergy or severe adverse reactions related to nalbuphine; 7. Refusal of signing informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gastrointestinal Failure score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Quality of Recovery, QoR-15;First Defecation Time;Borborygmus Resumption Time; | — |
Countries
China
Contacts
Public ContactQingyu Xiao
The First Affiliated Hospital of Shantou University Medical College
Outcome results
None listed