Breast cancer
Conditions
Interventions
Control group:Postoperatively, sufentanil 0.75ug/kg + dexmedetomidine 0.05ug/kg/h + tropisetron 10mg plus normal saline to 100ml were used for analgesic management, and the drug was administered throu
Experimental group:After the operation, butorphanol 0.15mg/kg + dexmedetomidine 0.05ug/kg/h + tropisetron 10mg plus normal saline to 100ml were used for administration through an intravenous self-cont
Sponsors
Shenzhen Second People's Hospital
Eligibility
Sex/Gender
Female
Age
19 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age > 18 years; 2.The participant voluntarily joins the study and signs the informed consent form; 3.Patients with breast cancer confirmed by pathology are scheduled to undergo radical mastectomy or modified radical mastectomy; 4.American Society of Anesthesiologists (ASA) physical status classification of Grade I-II.
Exclusion criteria
Exclusion criteria: 1.Severe preoperative cardiac, pulmonary, hepatic, or renal insufficiency; 2.History of psychiatric disorders or long-term use of antiepileptic drugs, antidepressants, sedative-hypnotics, or other psychotropic medications; 3.Known allergy to sufentanil, butorphanol, dexmedetomidine, tropisetron, or related agents; 4.BMI 30 kg/m^2; 5.Long-term opioid therapy for chronic pain before surgery; 6.Severe preoperative sinus bradycardia (heart rate < 50 bpm), sick sinus syndrome, second-degree or higher atrioventricular block, or presence of a pacemaker; 7.Pregnancy or lactation; 8.Recent major life events that could affect quality of life; 9.Advanced breast cancer with widespread metastasis; 10.Concomitant malignancy present preoperatively; 11.Preoperative intellectual disability or cognitive impairment preventing effective communication; 12.Any other condition that, in the investigator’s judgment, makes the patient unsuitable for the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative quality of life; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pain level;Sleep quality;Anxiety/depressive state;Postoperative adverse reactions;Postoperative fatigue;Use of postoperative analgesics;Patient satisfaction; | — |
Countries
China
Contacts
Public ContactYang xinping
Shenzhen Second People's Hospital
Outcome results
None listed