allergic asthma
Conditions
Interventions
experimental group:Subcutaneous rush immunotherapy regimen
normal group:Subcutaneous Conventional immunotherapy
Sponsors
General Hospital of Northern Theater Command of PLA
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: (1) Age: 18-60 years old, meeting the diagnostic criteria of allergic asthma, with or without allergic rhinitis or conjunctivitis; (2) Skin prick test positive for dust mite allergen (>= grade 2); (3) serum dust mite specific ige antibody positive (>= grade 2); (4) patients with stable mild or moderate allergic asthma; (Mild asthma: complete control after stage 1 and stage 2 treatment; Moderate asthma: fully controlled with stage 3 treatment.); (5) Previous history of allergic asthma acute attack; (6) With the consent of the patients, they signed the informed consent and received regular follow-up;
Exclusion criteria
Exclusion criteria: (1) severe uncontrolled asthma (FEV1<70%); (2) with acute or chronic lung diseases, malignant tumors, abnormal heart, liver and kidney, autoimmune diseases, mental disorders, etc.; (3) chronic obstructive pulmonary disease, atelectasis and other respiratory diseases; (4) Patients had poor compliance during follow-up and were not actively cooperative or willing to participate in this study; (5) patients allergic to epinephrine; (6) patients who had received allergen specific immunotherapy or other biological agents.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The time of the first attack of allergic asthma after treatment; | — |
Secondary
| Measure | Time frame |
|---|---|
| Percentage of blood eosinophils;Total serum IgE;Serum specific IgE;sIgE/tIgE;skin prick test;Total number of asthma exacerbations in 12 months;Number of use of ventolin;Visual analogue scale (VAS) for asthma and rhinitis;Daily total medication Score (DMS);Asthma Quality of Life questionnaire (AQLQ) score;Asthma Control Test Score (ACT);Lung function; | — |
Countries
China
Contacts
Public ContactChai Ruonan
General Hospital of Northern Theater Command
Outcome results
None listed