Stroke
Conditions
Interventions
Experimental group of stroke patients:Intermittent Theta-Burst Stimulation (iTBS) and Upper-Limb Rehabilitation Training with Brain–Computer Interface (BCI): Participants received a three-week interv
Control group of stroke patients:Sham iTBS and Upper-Limb Rehabilitation Training with Brain–Computer Interface (BCI) in the Pre-Frontal Cortex and Motor Cortex Regions (Three-Week Intervention)
Experimental group of healthy subjects:One Week of BCI Upper-Limb Rehabilitation Training, Followed by a Single Session of Real iTBS in the Prefrontal Cortex and Motor Cortex Combined with BCI Upper-L
Control group of healthy subjects:One Week of BCI Upper-Limb Rehabilitation Training, Followed by a Single Session of Sham iTBS in the Prefrontal Cortex and Motor Cortex Combined with BCI Upper-Limb R
Sponsors
Guangdong Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for stroke patients: (2)Upper-limb motor function impairment as evidenced by clinical presentation within 18 months post-stroke. (2)Montreal Cognitive Assessment (MoCA) score >= 22. (3)Bilateral visual acuity or corrected visual acuity >= 1.0 as assessed by the international standard visual acuity chart. (4)No metallic implants in the body. (5)Ability to follow instructions for testing procedures. (6)Voluntary provision of informed consent. Inclusion criteria for healthy participants: (1)Good general health status. (2)No neuromuscular diseases or pain in the upper limbs, with normal joint range of motion. (3)No history of upper-limb trauma or surgery within the past three years. (4)No history of neurological or psychiatric disorders. (5)Bilateral visual acuity or corrected visual acuity >= 1.0 as assessed by the international standard visual acuity chart. (6)No metallic implants in the body. (7)Voluntary provision of informed consent.
Exclusion criteria
Exclusion criteria: Exclusion criteria for stroke patients: (1) Non-unilateral hemispheric stroke. (2) History of previous stroke, brain tumor, traumatic brain injury, or other neurological or psychiatric disorders. (3) Presence of cognitive impairment. (4) Severe comorbidities involving the heart, lungs, liver, pancreas, kidneys, or other major organs. (5) Severe visual impairment. (6) Inability to cooperate with assessments or treatments. (7) Refusal to provide informed consent. Exclusion criteria for healthy participants: (1) Upper-limb motor dysfunction or pain due to neuromuscular diseases or trauma. (2) History of traumatic brain injury, stroke, or other neurological disorders. (3) Pregnancy. (4) Inability or unwillingness to cooperate with assessments. (5) Refusal to provide informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fugl-Meyer Assessment Scale, FMAS;Cognitive function tests; | — |
Secondary
| Measure | Time frame |
|---|---|
| Action Research Arm Test;ability of motor imagery;Intrinsic Motivation Inventory; | — |
Countries
China
Contacts
Public ContactQian Ding
Department of Rehabilitation Medicine, Guangdong Provincial People's Hospital
Outcome results
None listed