Invasive fungal infection
Conditions
Interventions
the elderly group:NA
the non-elderly group:NA
Sponsors
Zhengzhou Central Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.patients who met the criteria for diagnosis of IFI; 2.age >= 18 years; 3.The duration of voriconazole treatment course >= 5 days; 4.Draw at least one steady-state trough blood sample from each patient;
Exclusion criteria
Exclusion criteria: 1.Patients who allergic to voriconazole; 2.use other anti-fungal drugs; 3.pregnant or lactating women; 4.Hemodialysis patients; 5.patients who are treated with a combination of liver enzyme inducers and inhibitors (carbamazepine, phenobarbital, phenytoin, cimetidine, rifampin, rifapentine, rifabutin, and so on); 6.patients who haven’t completely and accurately data; 7.Participants in other clinical trials within 3 months;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cmin;CYP2C19 genotypes;Alanine aminotransferase;Aspartate aminotransferase;Alkaline phosphatase;Total bilirubin; | — |
Secondary
| Measure | Time frame |
|---|---|
| C-reactive protein;Procalcitonin;Interleukin-6; | — |
Countries
China
Contacts
Public ContactZhou Lijuan
Zhengzhou Central Hospital
Outcome results
None listed