Postoperative cognitive dysfunction
Conditions
Interventions
Test group:Anesthesia maintenance: During the operation, sevoflurane was inhaled at a concentration of 1.5%-3% and remifentanil was continuously pumped with 0.01-0.02µg/(kg·min) to maintain anesthesia
Control group:Anesthesia maintenance: During the operation, sevoflurane was inhaled at a concentration of 1.5%-3% and remifentanil was continuously pumped with 0.01-0.02µg/(kg·min) to maintain anesthe
Analgesic pump parameter settings: first dose 2ml, background dose 2.5ml/h, patient-controlled analgesia (PCA) dose 2ml, lock-in time 30min.
Sponsors
General Hospital of Western Theater Command of PLA
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >=65 years old; 2. American Society of Anesthesiologists (ASA) grade I-III; 3. Patients with indications for gastrointestinal tumor resection; 4. All patients received postoperative analgesia; 5. All patients or their family members voluntarily signed informed consent.
Exclusion criteria
Exclusion criteria: 1.ASA grade > III; 2. Previous history of stroke, cerebral infarction or TIA; Obstructive sleep apnea syndrome; 3. Patients with infectious diseases or hematological diseases; 4. Patients with end-stage chronic disease, severe pulmonary hypertension, acute myocardial infarction; 5. Patients with contraindications to surgery and anesthesia; 6. Patients with senile dementia, Alzheimer's disease and other brain degenerative diseases; 7. Those with mental disorder or mental illness who are unable to cooperate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Montreal Cognitive Assessment Score;Mini-mental State Examination Score;Interleukin-6 expression levels in serology;S100ß protein content in serology; | — |
Secondary
| Measure | Time frame |
|---|---|
| Gut microbiota;Quantitative of serum bile acids; | — |
Countries
China
Contacts
Public ContactLibang Yuan
General Hospital of Western Theater Command of PLA
Outcome results
None listed