perioperative neurocognitive disorders
Conditions
Interventions
Remazolam Group:Intravenous remazolam
Sponsors
Department of Anesthesiology, The First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital)
Eligibility
Sex/Gender
All
Age
18 Years to 59 Years
Inclusion criteria
Inclusion criteria: 1. Age 18-59 years old; 2. American Society of Anesthesiologists (ASA) Grades I - ? leIvel; 3. BMI 18.5 - 24 kg/m^2; 4. Patients who plan to undergo laparoscopic surgery under general anesthesia and are expected to be anesthetized for 2 to 4 hours.
Exclusion criteria
Exclusion criteria: 1.Patients with a prior history of memory impairment, cognitive impairment, neurological disorder, psychiatric disorder, or traumatic brain injury were clearly diagnosed; 2. Patients who are addicted to drugs or drugs or alcohol; 3. Patients with known or highly suspected intolerance or allergy to one of the narcotic drugs; 4. Patients with visual, hearing, presentation and other disorders that may affect the assessment of memory and cognitive function; 5. Patients who have received other operations or drugs (including but not limited to general anesthesia drugs) that may affect memory or cognition within one month before or one month after the operation; 6. Patients who used hormones or non-steroidal anti-inflammatory drugs within one week before surgery or within one month of planned surgery; 7. Patients with preoperative TRT score < 3 or preoperative MES score =<= 5.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Assessment of perioperative memory function;Assessment of perioperative cognitive function;The incidence of early postoperative memory impairment; | — |
Secondary
| Measure | Time frame |
|---|---|
| Plasma levels of IL-6, S100ß and NFL;Hemodynamic monitoring;Perioperative time indicators;Perioperative drug dosage; | — |
Countries
China
Contacts
Public ContactSheng Wang
Department of Anesthesiology, The First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital)
Outcome results
None listed