Stroke
Conditions
Interventions
Experimental group:Intermittent Theta burst stimulation combined with conventional rehabilitation therapy
Control group:5Hz repetitive transcranial magnetic stimulation combined with conventional physical therapy
Sponsors
Beijing Xiaotangshan Hospital
Eligibility
Sex/Gender
All
Age
30 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1 Meet the diagnostic criteria for stroke issued by the Chinese Society of Neurology, Chinese Medical Association, and be diagnosed as subcortical hemorrhagic stroke or subcortical ischemic stroke by head CT and/or MRI; 2 The injured hemisphere was unilateral, with unilateral limb motor dysfunction; 3 The onset of the first episode, the course of disease ranged from 15 days to 3 months; 4 Age 30 <= age <=75 years old; 5 Brunnstrom stage of upper limbs and hands was ?-IV; 6 The patient was right-handed before the onset. 7 clear consciousness, able to cooperate with physical examination, and without severe cognitive impairment; 8 All patients volunteered to participate in the iTBS or HF-rTMS treatment and signed the informed consent.
Exclusion criteria
Exclusion criteria: 1 metallic foreign body in the head, with implantable pulse stimulation generator or drug pump, cochlear implant; 2 people at high risk of noise-induced hearing loss (including those treated with ototoxic drugs and those exposed to solvents), people with hyperacusis symptoms; 3 Pregnant patients; 4 severe or recent heart disease; 5 history of epilepsy, severe heart, lung, liver, kidney and other important organ failure, and intracranial hypertension; 6 severe cognitive, communication disorders, emotional disorders, irritability and other inability to cooperate; 7 those who received iTBS or HF-rTMS within 3 months before the study; 8 Skull or hand defects; 9 The investigator considered it inappropriate to participate in the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fugl-Meyer Assessment of Upper Extremity;Upper limb muscle strength and tension;Wolf Motor Function Test;Stroke Impact Scale -16; | — |
Secondary
| Measure | Time frame |
|---|---|
| Motor Evoked Potential;Central Motor Conduction Time;Resting Motor Threshold;Current Perception Threshold;Semmes-Weinstein Monofilament;Action Research Arm Test score; | — |
Countries
China
Contacts
Public ContactLiang Wu
Beijing Xiaotangshan Hospital
Outcome results
None listed