Insufficient bone mass in dental implant alveolar bone
Conditions
Sponsors
West China Hospital of Stomatology Sichuan University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Age range of 18-70 years old (including upper and lower limits), gender is not limited; 2.Continuous loss of 2-3 tooth positions, and the duration of tooth loss is greater than 3 months; 3.Simple horizontal buccal bone defect, defect type is two wall or three wall bone defect, requiring simultaneous implantation Guided bone regeneration surgery; 4.Periodontal health, adjacent teeth health without restorations; 5.The patient voluntarily participates in the clinical study and signs the 'Informed Consent Form'.
Exclusion criteria
Exclusion criteria: 1.Patients with a history of preservation of alveolar bone sites in the tested tooth position; 2.Malignant tumors, active infectious lesions, and various defects generated during the active phase of metabolic bone diseases; 3.Patients with a history of acute periapical periodontitis, progressive periodontal disease, refractory periodontitis, severe habitual bruxism, infection, etc; 4.Patients with bone metabolism disorders (such as osteoporosis, abnormal osteoarthritis, etc.), or those who have taken drugs or products that can significantly affect bone metabolism (such as steroids, bisphosphonates, etc.) within the past 3 months before enrollment; 5.History of head and neck radiotherapy; 6.Patients who are unable to undergo oral imaging examinations and those who may experience dental imaging artifacts that affect outcome evaluation; 7.Patients who have taken anticoagulant drugs or have abnormal coagulation function in the past 3 months and are deemed unsuitable for surgery by researchers; 8.Patients with abnormal liver and kidney function (ALT and AST values exceeding 1.5 times the upper limit of normal, or creatinine exceeding normal); 9.Poorly controlled diabetes (fasting blood glucose >= 8 mmol/L), poorly controlled hypertension (systolic blood pressure >= 160 mmHg and/or diastolic blood pressure >= 100 mmHg); 10.Pregnant and intending pregnant women of childbearing age and lactating women; 11.Patients who smoke heavily (>= 10 cigarettes/day); 12.Patients with severe mental illness, alcohol or drug abuse; 13.The patient has participated in or is currently participating in clinical trials of other drugs or devices within the past 3 months; 14.Other patients deemed unsuitable for inclusion by researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes of average thickness of alveolar bone on labial and buccal side of implant; | — |
Secondary
| Measure | Time frame |
|---|---|
| Wound healing of gingival tissue in the implanted area; | — |
Countries
China
Contacts
Public ContactZhang Shiwen
West China Hospital of Stomatology Sichuan University
Outcome results
None listed