patients undergoing laparoscopic hysterectomy:
Conditions
Interventions
Lidocaine Group: Intervention Measures for the Lidocaine Group
**1. Treatment Period**: From the initiation of anesthesia induction to 24 hours after the end of surgery.
**(1) Anesthesia Protocol**:
Sponsors
Dongguan People's Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1)Age: 18-65 years old; 2)American Society of Anesthesiologists (ASA) physical status classification I-III; 3)Patients scheduled to undergo elective laparoscopic hysterectomy under general anesthesia; 4)Participants fully understand the purpose and significance of this trial, voluntarily agree to participate in this clinical trial, and sign an informed consent form.
Exclusion criteria
Exclusion criteria: 1) Body weight less than 40 kg or greater than 100 kg; 2) Arrhythmia or systolic heart failure: second- or third-degree atrioventricular block, EF < 50%; 3) Severe liver dysfunction: AST, ALT, or bilirubin levels exceeding 2.5 times the upper limit of normal; 4) Severe renal dysfunction: creatinine clearance rate less than 60 ml/min; 5) Presence of metastatic disease in other organs; 6) Allergy to any of the trial medications; 7) Long-term use of opioid medications; 8) Inability to understand the Numeric Rating Scale (NRS) for pain assessment; 9) History of asthma or preoperative findings suggesting the possibility of asthma;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of moderate to severe movement-evoked pain within 24 hours postoperatively.; | — |
Secondary
| Measure | Time frame |
|---|---|
| The incidence of moderate to severe movement-evoked pain within 48 hours postoperatively.;The incidence of moderate to severe pain at rest within 24 hours and 48 hours postoperatively.;The cumulative opioid consumption within 24 hours and 48 hours postoperatively.;The time to recovery of gastrointestinal function (i.e., the time of the patient's first postoperative bowel movement or flatus).;The incidence of PONV within 48 hours postoperatively (including any nausea or vomiting occurring within the first 48 hours after surgery).;The incidence of postoperative pulmonary complications during the hospital stay.;Length of hospital stay (defined as the period from the end of surgery to discharge).;Patient satisfaction score.;Pain relief score; | — |
Countries
China
Contacts
Public ContactHaihui Xie
Dongguan People's Hospital
Outcome results
None listed