atopic dermatitis
Conditions
Interventions
Abuxitinib treatment group:None
Sponsors
Guangzhou Dermatology Hospital
Eligibility
Sex/Gender
All
Age
12 Years to 17 Years
Inclusion criteria
Inclusion criteria: (1) Age between 12-17 years old; (2) The diagnosis of AD was confirmed by two professional dermatologists, and the diagnostic criteria were based on Williams criteria (determining diagnosis: primary criteria+3 or more secondary criteria). ·Main diagnostic criteria: Symptoms of skin itching; ·Secondary diagnostic criteria: History of involvement on the flexed side, including the elbow fossa, popliteal fossa, ankle anterior, and neck; History of asthma or allergic rhinitis; In recent years, there has been a history of dry skin throughout the body; Eczema on the flexed side; Onset before the age of 2; (3) The patient did not use traditional immunosuppressants, small molecule targeted drugs, or biologics within the first 3 months of enrollment; (4) During screening, the severity of AD in patients met the criteria of EASI >= 16 SCORAD>=25IGA>=3,Itch/sleep-NRS>=4.
Exclusion criteria
Exclusion criteria: (1) Severe infection (active tuberculosis, hepatitis B, HIV infection, etc.); (2) Those who are currently receiving or preparing to receive live or attenuated vaccines; (3) Immunocompromised individuals; (4) Individuals who are allergic to Abu Xitinib and any drug ingredients it contains; (5) Other systemic diseases or active skin diseases (such as psoriasis or lupus erythematosus) that may affect AD or research results exist; (6) Significant abnormalities in heart, liver, and kidney function results that affect the medication user; (7) Researchers consider participants who are uncooperative or unable to follow the research process.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| clinical efficacy score; | — |
Secondary
| Measure | Time frame |
|---|---|
| cytokine;total IgE; | — |
Countries
China
Contacts
Public ContactXibao Zhang
Guangzhou Dermatology Hospital
Outcome results
None listed