Osteoarthritis
Conditions
Interventions
Experimental Group:Intraoperative local infiltration injection of 266mg liposomal bupivacaine suspension (20mL liposomal bupivacaine+60mL physiological saline prepared as suspension) around the joint.
Control Group:Intraoperative local infiltration injection of analgesic drugs (ropivacaine 200 mg, dexamethasone 1 mL (containing 5 mg of betamethasone dipropionate and 2 mg of betamethasone disodium p
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1) Patients diagnosed with end-stage hip disease before surgery and requiring initial unilateral THA; 2) Agree to participate in the clinical trial and sign the informed consent form; 3) Age range: 18-80 years old.
Exclusion criteria
Exclusion criteria: 1) History of using anesthesia drugs for more than 3 months prior to surgery; 2) Due to various reasons before surgery, chronic anesthetics are currently needed; 3) Allergies to bupivacaine or ropivacaine; 4) Previous fractures; 5) Severe liver and kidney dysfunction; 6) Being pregnant or breastfeeding; 7) Joint revision, patients with joint infections; 8) Patients who are allergic to other drugs used in this experiment; 9) Patients who refuse to participate in this experiment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Rest or dynamic pain visual analog scale;Postoperative opioid use; | — |
Secondary
| Measure | Time frame |
|---|---|
| Joint Range of Motion;Wound complications;90 day postoperative readmission rate;Postoperative mortality at 90 days;Adverse reactions associated with liposomal bupivacaine; | — |
Countries
China
Contacts
Public ContactZeng Weinan
West China Hospital of Sichuan University
Outcome results
None listed