Alzheimers disease
Conditions
Interventions
Group A Intervention Group:Deep cervical lymphatic-venous anastomosis
Group B Control group:Non-surgical treatment
Sponsors
Kunming Sanbo Brain Hospital
Eligibility
Sex/Gender
All
Age
50 Years to 85 Years
Inclusion criteria
Inclusion criteria: (1) Clinical diagnosis consistent with Alzheimer's disease-related cognitive impairment or Alzheimer's disease with dementia; (2) Age between 50 and 85 years (inclusive), regardless of gender; (3) Moderate to severe cognitive decline (MMES <= 20 points or MoCA < 20 points); (4) Patients with Alzheimer's disease (AD) who are unable or unwilling to be treated by other methods; (5) Disease duration of 6 months or longer, with conservative treatment for 3 months or longer; (6) Ability to complete the cognitive and other tests specified in the project protocol as required; (7) Presence of a stable and reliable caregiver, or frequent contact with a caregiver (at least 4 days per week, for more than 2 hours each day), and the caregiver or immediate family member is willing to sign the informed consent form to assist the participant in this study. The caregiver is required to accompany the participant to the study visits and have sufficient interaction and communication with the participant to provide the necessary information for the study.
Exclusion criteria
Exclusion criteria: (1) Presence of unassessed or untreated moderate to severe hydrocephalus, brain tumors, and other serious cranial diseases; (2) History of severe traumatic brain injury, large cerebral infarction, craniotomy for cerebral hemorrhage, and severe intracranial infection; (3) Presence of uncontrolled systemic infection or surgical site infection; (4) Coexisting malignant tumors of the cranial and peripheral regions with a life expectancy of less than one year; (5) Hematological diseases and coagulation mechanism disorders (hypercoagulable or hypocoagulable states); (6) Other conditions that cannot tolerate anesthesia and surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intelligence (MMSE, MoCA and ADL scales );ß amyloid;Tau; | — |
Countries
China
Contacts
Public ContactHaoRan Wang
Kunming Sanbo Brain Hospital
Outcome results
None listed