Attention deficit hyperactivity disorder, tic disorders,epilepsy
Conditions
Interventions
Attention deficit hyperactivity disorder (ADHD):None
Control group :None
Sponsors
Affiliated hangzhou first people's hospital, zhejiang university school of medicine
Eligibility
Sex/Gender
All
Age
3 Years to 12 Years
Inclusion criteria
Inclusion criteria: 1.Inclusion criteria for the case group: children aged 3-12 years; children diagnosed with ADHD, Tourette's syndrome or epilepsy by at least two senior pediatric neurologists according to international authoritative diagnostic standards, such as the Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition) (DSM-5), and the professional diagnostic guidelines for related disorders; children have not received treatment that may affect the metabolism of vitamin D or vitamin B in the last month prior to the study; children and their guardians understand the content of the study and are willing to cooperate with the study process, Vitamin D metabolism, such as high-dose glucocorticoid shock therapy, long-term use of immunosuppressive drugs, etc.; children and their guardians can understand the content of the study and sign a written informed consent form, and are willing to actively cooperate with the completion of the entire study process, including regular follow-up visits and various examinations. Disease subgroups: Based on the above enrollment criteria, the case group was subdivided into 3 subgroups of hyperactivity disorder, tic disorder, and epilepsy, with at least 800 cases in each group. 2.Inclusion criteria of the control group: healthy children aged 3-12 years old; exclude neurological, psychiatric, respiratory, circulatory, digestive, urinary, endocrine, reproductive and other systemic diseases after evaluation; have not received treatment that may affect the metabolism of vitamin B and vitamin D, such as high-dose glucocorticosteroid shock therapy, long-term use of immunosuppressive drugs, etc., in the past 1 month prior to the enrollment; the children and their guardians understand the content of the study, and sign a written informed consent, willing to cooperate with the completion of the study process, including regular follow-up examinations. The children and their guardians can understand the content of the study and sign a written informed consent form, and are willing to actively cooperate with the completion of the entire study process, including regular follow-up visits and various examinations.
Exclusion criteria
Exclusion criteria: 1.Exclusion criteria for the case group: other serious neurodegenerative diseases, such as Parkinson's disease, Huntington's disease, etc.; congenital heart disease, various types of physical disabilities, chronic renal failure, autoimmune diseases and other systemic diseases that may significantly interfere with vitamin B and vitamin D metabolism and immune regulation; intellectual disability or other serious cognitive deficits, unable to cooperate in completing the relevant assessment and testing; history of major trauma, surgery or infectious disease episodes within 6 months, which may affect the immune and metabolic status of the body. History of major trauma, surgery, or infectious disease episodes within the last 6 months that may affect the immune and metabolic status of the body. 2.Exclusion criteria for the control group: inability to cooperate in completing relevant assessments and tests; history of major trauma, surgery, or infectious disease episodes in the last 6 months, which may affect the immune and metabolic status of the body.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Vitamins B and D and their receptor gene polymorphisms; | — |
Countries
China
Contacts
Public ContactChunming Jiang
Affiliated hangzhou first people's hospital, zhejiang university school of medicine
Outcome results
None listed