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Prediction of inflammatory factors and oxidative stress indicators in perinatal cerebrospinal fluid and venous blood on postpartum depression in women delivered by cesarean section

Prediction of inflammatory factors and oxidative stress indicators in perinatal cerebrospinal fluid and venous blood on postpartum depression in women delivered by cesarean section

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500097571
Enrollment
Unknown
Registered
2025-02-20
Start date
2024-04-01
Completion date
Unknown
Last updated
2025-02-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

postpartum depressive

Interventions

control:On the third day after surgery, the women with an EPDS score of = 10 were assessed by the Edinburgh Postpartum Depression Scale (EPDS) and were assigned to the case group

Sponsors

Henan Provincial People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 33 Years

Inclusion criteria

Inclusion criteria: 1.Age > = 24 years 2.ASA is graded as I.~II 3.Gestational age > = 37 weeks 4.Cesarean section is intended to be performed under subarachnoid block anesthesia 5.No history of depression, mental disorder, brain disease, intellectual disability, endocrine disease, severe physical trauma and other diseases 6.Agree to participate in this study and voluntarily sign the informed consent form

Exclusion criteria

Exclusion criteria: 1.Gestational age = 35 kg/m² on the day before surgery 3.Combined with placental abruption, macrosomia, twins, and multiple births 4.Combined with other diseases: malignant tumors, heart, liver and kidney failure, major organ diseases, mental diseases, brain diseases, eclampsia, gestational hypertension, hyperthyroidism, systemic immune system diseases and coagulation disorders 5.Prenatal depression was judged by the Hamilton Depression Scale 6.History of addiction to narcotic drugs, history of allergy to narcotic drugs 7.Serious complications after cesarean section, such as postoperative hemorrhage

Design outcomes

Primary

MeasureTime frame
Edinburgh postnatal depression Scale score;TNF-a;INF-?;C-reactive protein;Brain-derived neurotrophic factor;Superoxide?Dismutase;Glutathione;Glutathione;

Countries

China

Contacts

Public ContactDou lidong

Henan Provincial People's Hospital

dould21@163.com+86 155 4416 0565

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026