Acute Pancreatitis
Conditions
Interventions
Goal-Directed Resuscitation Group:First, assess the initial volume status. If any of the following three conditions exist, initiate fluid resuscitation
otherwise, administer 1.0-1.5 mL/kg/h of lactated Ringer's solution (LR) until the patient can tolerate oral feeding for more than 8 hours.
? Insufficient tissue perfusion: lactate > 2 mmol/L
? Blood concentration: Hb or/and HCT higher than normal values
? Hypotension: mean arterial pressure 40 mmHg from baseline.
Fluid resuscitation process: First, administer at least 20 mL/kg of lactated Ringer's solution (LR) within 2 hours. Then, evaluate the res
Speed Recovery Group:Firstly, administer a continuous infusion of 1.5 mL/kg/h of Ringer's lactate solution (LR). If there is low blood volume, administer the first dose of 10 mL/kg of rapid infusion w
B. There is liquid overload, reduce or stop liquid infusion
C. Normal blood volume, continue infusion at a rate of 1.5 mL/kg/h.
The above-mentioned liquid resuscitation lasts for 20 hours. If the patien
Sponsors
Run Run Shaw Hospital Affiliated to Zhejiang University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Diagnosis is consistent with acute pancreatitis. Admitted to the hospital within 24 hours of onset (the onset time is calculated based on the time of abdominal pain). Age > = 18 years old and < = 70 years old.
Exclusion criteria
Exclusion criteria: Pregnant woman. Patients with recurrent episodes of chronic pancreatitis. Patients with underlying chronic cardiac insufficiency, chronic renal insufficiency, decompensated cirrhosis, malignancy, or post-pacemaker implantation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of organ failure; | — |
Countries
China
Contacts
Public ContactGuo Feng
Run Run Shaw Hospital Affiliated to Zhejiang University School of Medicine
Outcome results
None listed