Anxiety Disorder
Conditions
Interventions
Healthy Control Group:None
Sponsors
Xijing Hospital, the Fourth Military Medical University, Xi'an, China
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: I. Anxiety Disorder Group 1. Approval from the Ethics Committee was obtained, and all participants (or their guardians) provided written informed consent; 2. 200 patients with anxiety disorders meeting the DSM-5 diagnostic criteria; Hamilton Anxiety Scale (HAMA) score >=14; age 18-65 years; 3. No use of prebiotics, probiotics, or probiotic-fermented foods within the past month; 4. No use of any antibiotics within the past month. II. Healthy Control Group 1. Approval from the Ethics Committee was obtained, and all participants (or their guardians) provided written informed consent; 2. 100 adults, aged 18-65 years; 3. No use of prebiotics, probiotics, or probiotic-fermented foods within the past month; 4. No use of any antibiotics within the past month.
Exclusion criteria
Exclusion criteria: 1. Presence of the following diseases: Gastrointestinal diseases: Inflammatory bowel disease, Crohn's disease, pancreatitis, fatty liver, etc. Coronary heart disease. Systemic autoimmune diseases (e.g., systemic lupus erythematosus, Behçet's disease, multiple sclerosis, connective tissue diseases). Atopic diseases (e.g., moderate to severe asthma, eczema, gastrointestinal eosinophilic disorders). Chronic pain syndromes (e.g., chronic fatigue syndrome, fibromyalgia). Neurological/neurodevelopmental disorders. 2. Obesity or metabolic abnormalities: Obesity: BMI >= 28.0. Hyperglycemia: Fasting plasma glucose (FPG) >= 6.1 mmol/L and/or 2-hour postprandial glucose (2hTC) >= 7.8 mmol/L and/or individuals who have been treated for diabetes. Hypertriglyceridemia: Triglycerides (TG) >= 2.3 mmol/L. Hypertension: Systolic blood pressure >= 140 mmHg or diastolic blood pressure >= 90 mmHg. 3. Pregnant or breastfeeding women. 4. Individuals with special dietary or lifestyle preferences. 5. Presence of other psychiatric disorders that meet the diagnostic criteria of the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). 6. Use of any psychotropic medications or antipyretic analgesics within the past 2 weeks.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Diversity of gut microbiota;Hamilton Anxiety Scale (HAMA);Panic Disorder Severity Scale (PDSS);Liebowitz Social Anxiety Scale (LSAS);Generalized Anxiety Disorder scale (GAD-7);blood metabolomics; | — |
Countries
China
Contacts
Public ContactPeng Zhengwu
Xijing Hospital, the Fourth Military Medical University, Xi'an, China
Outcome results
None listed