Tic disorders
Conditions
Interventions
Zonisamide Monotherapy Group:None
Tiapride Monotherapy Group:None
Zonisamide-Tiapride Combination Therapy Group:None
Sponsors
Children's Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Age
1 Months to 18 Years
Inclusion criteria
Inclusion criteria: (1) Meeting the diagnostic criteria for TD as defined by the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, Text Revision (DSM-5-TR); (2) Aged = 25; (4) Medication-naive status with no concurrent behavioral or pharmacological therapies; (5) Written informed consent obtained from both guardians and pediatric patients.
Exclusion criteria
Exclusion criteria: (1) TD secondary to Sydenham chorea, Wilson disease, epileptic myoclonic seizures, or other neurological pathologies; (2) Contraindications including hypersensitivity to study medications or clinically significant hepatic/renal dysfunction; (3) Inability to complete the trial protocol due to poor adherence or geographic relocation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Yale Global Tic Severity Scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Infants-Junior Middle School Students' Social-Life Abilities Scale;Sandplay Therapy; | — |
Countries
China
Contacts
Public ContactXiao Nong
Children's Hospital of Chongqing Medical University
Outcome results
None listed