Bone resorption after iliac flap reconstruction of jaw defect
Conditions
Interventions
Simultaneous bone extraction group (Bone was taken at the same time as implantation):None
Secondary bone collection group (Bone was taken when implants were performed 6 months or more after jaw reconstruction surgery):None
Sponsors
Peking University Hospital of Stomatology
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1.Patients who wish to undergo implant denture repair after surgery; 2.Patients requiring vascularized free iliac myocutaneous flap repair due to tumor resection or trauma in the upper/lower jaw; 3.At least 1 segment of the iliac crest is used to repair the alveolar ridge area;
Exclusion criteria
Exclusion criteria: 1.After operation, titanium plate exposure, infection and flap failure occurred; 2.Patients have systemic diseases that affect bone metabolism and take systemic medications that affect bone metabolism; 3.Patients who, for some reason, are ultimately unable to undergo implant denture restoration;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proliferation and differentiation of BMSC; | — |
Secondary
| Measure | Time frame |
|---|---|
| Expression differences of Pizeo I and its related genes;Differences in expression of osteoblast-related genes;Expression difference of osteoclast-related genes;Expression difference of Piezo I related genes between patients undergoing simultaneous implantation and those undergoing secondary implantation;Osteoblast-mediated bone formation;Osteoclast-mediated bone resorption capacity; | — |
Countries
China
Contacts
Public ContactXiaofeng Shan
Peking University Hospital of Stomatology
Outcome results
None listed