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Clinical studies of clicking the teeth to promote tissue repair in the inflammatory setting of periodontal disease

Clinical studies of clicking the teeth to promote tissue repair in the inflammatory setting of periodontal disease

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500097489
Enrollment
Unknown
Registered
2025-02-19
Start date
2025-03-01
Completion date
Unknown
Last updated
2025-02-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

parodontopathy

Interventions

Experimental group ( clicking the teeth group):The patient clicking the upper and lower teeth 30 every time.No more than 2 minutes at each time and 3 times a day (morning, noon, evening).
Control group:Only brush teeth and floss.

Sponsors

The Third Affiliated Hospital of the Air Force Military Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Periodontitis (stage I and stage II) patients need to meet the following inclusion criteria: 1) Age is greater than 18 (including 18 years old), and gender is not limited; 2) At least 20 natural teeth are retained in the mouth, without tooth loss due to periodontitis; 3) The heaviest CAL site on the adjacent surface is 1-4mm; 4) Periodontal exploration depth of 5mm; 5) Imaging bone loss is located in 1 / 3 of the root and crown square, mainly caused by horizontal bone resorption; 6) No periodontal treatment in the last three months; 7) Did not take antibiotics in the past one month; 8) Clear awareness, able to answer correctly, able to cooperate with the research, 9) Voluntary participation and the signing of the informed consent form 10) Be able to understand and master the essentials of percussion teeth, and have good compliance Patients with chronic gingivitis should meet the following inclusion criteria: 1) Age is greater than 18 (including 18 years old), and gender is not limited; 2) Keep at least 20 natural teeth in the mouth; 3) Chronic gingivitis was diagnosed according to the diagnostic criteria; 4) No periodontal treatment in the last three months; 5) Did not take antibiotics in the past one month; 6) Clear consciousness, able to answer correctly, able to cooperate with the research, 7) Voluntary participation and the signing of the informed consent form 8) Be able to understand and master the essentials of percussion teeth, and have good compliance

Exclusion criteria

Exclusion criteria: 1) There are acute infection areas in the mouth, such as acute pulpitis, periapical periodontitis, periodontal abscess, gap infection, etc.; 2) Women with a recent fever, allergies, alcoholism, pregnancy or breastfeeding; 3) Salivary gland diseases such as salivary gland stones, inflammation of salivary gland or salivary gland tumors; 4) Dry eromouth patients; 5) HIV or active HBV or HCV infection; 6) Patients treated with immunosuppressive therapy; 7) Having a hemorrhagic disease; 8) Patients with malignant tumours; 9) Chronic renal failure or liver cirrhosis; 10) Take drugs that affect bone metabolism or the gums; 11) Other patients considered unsuitable by the investigator.

Design outcomes

Primary

MeasureTime frame
Differences in alveolar bone mass levels;TNF-a;IL-1ß;IL-6;IL-10;POSTN;ROS;MDA;SOD;GSH-Px;

Secondary

MeasureTime frame
Conscious symptoms;gingival index;bleeding on probing;Gingival groove depth;probing depth;GAL;Gingival height;

Countries

China

Contacts

Public ContactZhang Min

The Third Affiliated Hospital of the Air Force Military Medical University

937122907@qq.com+86 136 8929 6917

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026