ARDS
Conditions
Interventions
Control group:No
iPSC-Exo group:iPSC-Exo atomization therapy
Sponsors
children’hospital capital institute of pediatric
Eligibility
Sex/Gender
All
Age
1 Years to 12 Years
Inclusion criteria
Inclusion criteria: 1. Age 1 to 12 years old; No gender limitation. 2. Children diagnosed with moderate to severe ARDS and expected to undergo mechanical ventilation for >24 hours. 3. The course of the disease was within 96 hours after the diagnosis of ARDS. 4. Obtain the informed consent of the guardian.
Exclusion criteria
Exclusion criteria: 1. Patients with severe allergies; Allergic to cell products; 2. Children with severe chronic respiratory diseases, PaCO2 > 50mmHg, requiring home oxygen therapy; 3. Moderate to severe liver failure; 4. Undergoing hemodialysis or peritoneal dialysis treatment; 5. Active malignant tumor; 6. Neuromuscular diseases; 7. Bone marrow transplant; 8. Congenital immunodeficiency, or secondary immunodeficiency; 9. Patients receiving extracorporeal circulation support (ECMO); 10. Severe congenital malformation, chromosome disease; 11. Terminal illness.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in oxygenation index from baseline to day 7; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of serious adverse events;Murray lung injury Score;Mechanical ventilation time;ICU stay;28-days survival rate;Inflammatory index change; | — |
Countries
China
Contacts
Public ContactLiu Shuang
children’hospital capital institute of pediatric
Outcome results
None listed