Lumbar Spine Disease
Conditions
Interventions
Experimental group:Liposomal block of thoracolumbar fascia with bupivacaine caine
Control group:Thoracolumbar fascia block with ropivacaine
Control group:Local infiltration of bupivacaine liposomes
Sponsors
First Affiliated Hospital of Anhui Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1Clear lumbar spine disease by imaging examination, which meets the indication of lumbar spine fusion and internal fixation treatment; 2ASA grade I-III; 3. Age greater than 18 years old; 4. Normal communication; 5. Voluntarily undergo the test and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Emergency surgery; 2, with severe cardiac, hepatic or renal insufficiency; 3, the presence of infection, inflammation or injury at the puncture site; 4, Long-term use of analgesic drugs; 5, Allergy to liposomal bupivacaine or other anesthetic drugs in this study; 6, previous history of lumbar spine surgery; 7, Pregnant or lactating women; 8, inability to understand verbal or written information;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Patients' NRS pain scores at rest and after activity at 2h, 6h, 12h, 24h, 36h, 48h, and 72h after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Intraoperative anesthetic drug dosage: intraoperative propofol and remifentanil dosage, additional sufentanil dosage;40-item Quality of Recovery Rating Scale (QoR40) scores at 24, 48, and 72 hours postoperatively in all three groups of patients;Postoperative adverse effects: nausea, vomiting, postoperative delirium, dizziness and chest tightness;Post-operative recovery: first time off the floor and total length of hospitalization; | — |
Countries
China
Contacts
Public ContactKe Chen/Suli Wang/Chunyan Dou
First Affiliated Hospital of Anhui Medical University
Outcome results
None listed