lung cancer
Conditions
Interventions
Gold Standard:1.Surgical excision tissue biopsy
2.Enhanced MRI scan
Index test:The expression levels of cathepsin F and fibulin-1 in the cerebrospinal fluid and peripheral blood of patients. A diagnostic and predictive model for brain metastasis of lung cancer was con
Sponsors
Beijing Chest Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Confirmed by pathological diagnosis, patients with NSCLC accompanied by brain metastases according to the 2017 edition of staging for non-small cell lung cancer by the International Association for the Study of Lung Cancer (IASLC); 2. Confirmed as lung cancer by pathological diagnosis, accompanied by intracranial space-occupying lesions but clearly not brain metastases from lung cancer through follow-up observations; 3. Confirmed as primary brain diseases by pathological diagnosis, including schwannomas, gliomas, etc.; 4. Age >= 18 years old; 5. Able to comply with the treatment regimen; 6. Eastern Cooperative Oncology Group Performance Status (ECOG PS) score of 0 - 2; 7. Expected lifespan >= 12 weeks; 8. Adequate hematological function (including routine blood tests, liver function, kidney function, and electrolytes); 9. Able to undergo lumbar puncture for evaluation of cerebrospinal fluid; 10. Understand and voluntarily sign the written informed consent form.
Exclusion criteria
Exclusion criteria: 1. Having a history of severe cerebrovascular diseases in the past (such as large-area cerebral infarction or cerebral hemorrhage); 2. Having a history of other malignant tumors in the past; 3. Having a history of interstitial lung disease, drug-induced interstitial disease, radiation pneumonitis requiring hormone treatment, or any active interstitial lung disease with clinical evidence in the past; Patients with uncontrollable hemoptysis and gastrointestinal ulcers; 4. According to the judgment of the investigator, there is evidence of severe or uncontrollable systemic diseases (such as unstable or uncompensated respiratory, cardiac, liver or kidney diseases); 5. Any unstable systemic diseases (including active infections, grade 4 hypertension, unstable angina pectoris, congestive heart failure, liver, kidney or metabolic diseases); 6. Having a clear history of mental disorders in the past; 7. Pregnant women and lactating women; 8. Those who are considered by the investigator as not suitable to participate in this research project.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sensitivity and Specificity of the Diagnostic - Predictive Model for the Diagnosis of Patients with Brain Metastases from Lung Cancer; | — |
Secondary
| Measure | Time frame |
|---|---|
| Progression - Free Survival; | — |
Countries
China
Contacts
Public ContactSong Wei
Beijing Chest Hospital, Capital Medical University
Outcome results
None listed