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Effect of oxelidine on nausea and vomiting after laparoscopic total hysterectomy

Effect of oxelidine on nausea and vomiting after laparoscopic total hysterectomy

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500097470
Enrollment
Unknown
Registered
2025-02-19
Start date
2025-02-20
Completion date
Unknown
Last updated
2025-02-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

disease of uterus

Interventions

The Sufentanil group:Dilute Sufentanil 2ug/kg+ 0.9% sodium chloride to 100ml
Oxellidine low dose group:Oxelidine 0.1mg/kg+ 0.9% diluted to 100ml
Oxellidine medium dose group:Oxelidine 0.35mg/kg+ 0.9% diluted to 100ml
Oxellidine high dose group:Oxelidine 0.5mg/kg+ 0.9% diluted to 100ml

Sponsors

Shihezi University School of Medicine
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Female patients aged 18-65years ; 2. ASA grade I - II; 3. Be able to fill in and sign the informed consent in accordance with each rating scale

Exclusion criteria

Exclusion criteria: 1. Persons with a history of allergy to narcotic drugs and contraindications to opioids; 2. Severe respiratory depression ; 3. Patients with known or suspected gastrointestional obstruction; 4. Have a neurological disorder, long-term use of hypnotics or sedatives 5. Patients with moderate to severe hypertension and/or significantly elevated blood pressure that is life-threatening; 6. Patients with acute and chronic pain diseases; 7. Severe liver, liver and kidney dysfunction; 8. Refuse to sign informed consent, not the author

Design outcomes

Primary

MeasureTime frame
Postoperative nausea and vomiting incidence rate;Postoperative adverse reactions;

Secondary

MeasureTime frame
Postoperative analgesic drug dosage;Systolic blood pressure, diastolic blood pressure, mean arterial pressure (MAP), and heart rate (HR);Effective number of presses of postoperative analgesia pump;

Countries

China

Contacts

Public ContactDeng Jiaojiao

The First Affiliated Hospital of Shihezi University

99879434@qq.com+86 182 7565 8072

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026