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Study on the effect of cerebellar earthworm iTBS on homeostatic function and its neuromodulation mechanism in a debilitated elderly population

Study on the effect of cerebellar earthworm iTBS on homeostatic function and its neuromodulation mechanism in a debilitated elderly population

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500097468
Enrollment
Unknown
Registered
2025-02-19
Start date
2024-08-02
Completion date
Unknown
Last updated
2025-02-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Balance function in the frail elderly population

Interventions

intervention group:Subjects underwent combined motor training with iTBS true stimulation of the cerebellar vermis
control subjects:Combined motor training with iTBS pseudostimulation of the cerebellar vermis

Sponsors

West China Hospital of Sichuan University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
60 Years to No maximum

Inclusion criteria

Inclusion criteria: (1) Age 60 years and older; (2) Berg Balance Score of 21 to 45 before, at risk of falling, but can walk with assistance; (3) No severe cognitive dysfunction and MMSE >= 17 points; (4) Vital signs are stable and not associated with serious cardiac, pulmonary, circulatory, metabolic or other serious diseases that are not suitable for exercise; (5) Informed consent, voluntary subjects, the subjects themselves and their guardians signed the informed consent form.

Exclusion criteria

Exclusion criteria: (1) Severe incapacitation or the presence of other conditions (e.g., amputation, visual impairment, etc.) that severely affect the patient's balance function, resulting in the patient's inability to walk even with assistance; (2) Presence of contraindications to transcranial magnetic stimulation; (3) Participation in other clinical trials may affect the final evaluation results of this trial.

Design outcomes

Primary

MeasureTime frame
Berg balance scale score;

Secondary

MeasureTime frame
Balance Master score;MRI data;fNIRS;MBI score;

Countries

China

Contacts

Public ContactZuoyan Liu

West China Hospital of Sichuan University

zuo.yan.2008@163.com+86 28 8629 8034

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: May 27, 2026