Major depression disorder
Conditions
Interventions
iTBS-Active group:Use of transcranial magnetic stimulation (TMS) iTBS in the treatment of patients with anhedonia depression
iTBS-Sham group:Use of transcranial magnetic stimulation (TMS) iTBS in the treatment of patients with
anhedonia depression
Healthy control:None
Sponsors
Sixth People's Hospital of Hebei Province (Hebei Provincial Mental Health Center)
Eligibility
Sex/Gender
All
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: 1. Age 18-55 years; 2. Diagnosis of depression by more than two psychiatric attending physicians who understand and collaborate with this study according to the DSM-5 and screened by The Mini International Neuropsychiatric Interview (MINI) Fifth Edition; 3. Hamilton Depression Rating Scale-17 items (HAMD-17) > 17 points; 4. Psychiatrist assessed that there are obvious symptoms of anhedonia; 5. Dimensional Anhedonia Scale (DARS) self-rated total score 28 points; Current and prior use of CNS medications; right-handed; Understand the purpose of this study, be willing to participate, and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients with contraindications to rTMS treatment; 2.Patients with contraindications to fMRI scanning; 3. Lifetime or current diagnosis of other mental disorders based on DSM-5 axis I; 4. Depression caused by other psychoactive substances and independent substances; 5. Severe suicidal tendency or recent suicidal behavior; 6. Received rTMS treatment before enrollment or electroconvulsive therapy in the past six months, or had no response to the above treatment methods; 7. Long-term use of high-dose benzodiazepines (lorazepam > 2mg/ day or equivalent; 8. Moderate or above abnormal electroencephalogram; 9. Pregnant or lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton Depression Rating Scale score;Dimensional Anhedonia Rating Scale score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Sneth Hamilton Pleasure Scale score; | — |
Countries
China
Contacts
Public ContactWang Qi; Li Keqing
Sixth People's Hospital of Hebei Province (Hebei Provincial Mental Health Center)
Outcome results
None listed