Acute kidney injury
Conditions
Interventions
Flurbiprofen axetil group:flurbiprofen axidate 100mg was injected intravenously after the operation and before recovery from anesthesia
Control group:10ml of normal saline was injected intravenously after the operation and before recovery from anesthesia
Sponsors
Huadu District People's Hospital of Guangzhou
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients with normal serum creatinine and eGFR before surgery 2. Patients undergoing percutaneous nephrolithotomy under general anesthesia; 3.ASA grades 1-3; 4. BMI>18Kg/m2 and <30Kg/m2; 5. Patients or their family members can provide written informed consent.
Exclusion criteria
Exclusion criteria: 1. Perioperative use of other non-steroidal anti-inflammatory drugs; 2. Patients with contraindications to the use of flurbiprofen exate; 3. Preoperative CKD stage 3 (eGFR 1500ml); 8. Intraoperative hypotension (blood pressure below 90/60mmHg or MAP< 60mmHg for more than 20 minutes); 9. Patients in critical condition who need to be admitted to ICU for further treatment after surgery; 10. Severe liver dysfunction (Child-Pugh grade C); 11. Difficulty in follow-up and request for withdrawal from the investigator; 12. Patients with sepsis ;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum creatinine;Neutrophil gelatinase-associated lipocalin;Cystatin C; | — |
Countries
China
Contacts
Public ContactDong Wang
Huadu District People's Hospital of Guangzhou
Outcome results
None listed