Enhancing Neuromuscular Adaptations in Chronic Ankle Instability: A Study on the Combined Effects of Transcranial Direct Current Stimulation on Arthrogenic Muscle Inhibition (AMI)

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2500097439

Enrollment

Unknown

Registered

2025-02-19

Start date

2024-09-02

Completion date

Unknown

Last updated

2025-02-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic ankle instability

Interventions

tDCS group:tDCS intervention with balance ball training in rehabilitation

Sham-tDCS group:Sham-tDCS intervention with balance ball training in rehabilitation

Eligibility

Sex/Gender

All

Age

18 Years to 40 Years

Inclusion criteria

Inclusion criteria: (1) Age range of 18-40 years. (2) self-reported history of the first acute ankle sprain more than one year ago; (3) experience of two or more sprains to the same ankle in the three months prior to study; (4) at least two episodes of slack or ‘giving-way’ associated with the same ankle in the six months prior to participation; (5) a Cumberland Ankle Instability Tool (CAIT) score less than 24

Exclusion criteria

Exclusion criteria: (1) any self-reported neurological disease other than CAI known to significantly affect motor control (e.g., cerebellar diseases, cerebral palsy, stroke, dementia, etc.) (2) history of lower extremity surgery or fracture; or (3) currently active in another rehabilitative intervention program.

Design outcomes

Primary

Measure	Time frame
central activation ratio ;	—

Secondary

Measure	Time frame
H-reflex;	—

Countries

China

Contacts

Public ContactPing Zhang

Shandong Sport University/ Loughborough University

wo1sh1@msn.com+86 185 7559 2212

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026