None
Conditions
Interventions
Dexmedetomidine Nasal Spray Group:On the night before surgery, before the participant goes to sleep (before 12 p.m.), Dexmedetomidine Nasal Spray will be administered
control group:On the night before surgery, before the participant goes to sleep (before 12 p.m.), normal saline nasal spray will be administered.
Sponsors
Deyang People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.American Society of Anesthesiologists (ASA) classification Grade I to III; 2.Aged 18 to 65 years old; 3.Able to understand the research process and communicate effectively with researchers; 4.BMI of 18 to 30 kg/m²; 5.Patients scheduled for elective laparoscopic colorectal surgery; 6.Voluntary participation and signing of the informed consent form;
Exclusion criteria
Exclusion criteria: 1.Individuals allergic to Dexmedetomidine Nasal Spray and its components; 2.Patients with sinus bradycardia, sick sinus syndrome, second-degree or higher atrioventricular block; heart failure, NYHA classification Grade III or IV, hypotensive patients; 3.Patients with severe liver disease (Child-Pugh classification Grade B or C); 4.Patients with renal insufficiency (glomerular filtration rate < 30 ml/min·1.73m²); 5.Patients with other severe systemic diseases, such as leukemia, myasthenia gravis, etc. 6.Patients planned to be transferred to the intensive care unit postoperatively;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The quality of recovery at 24 hours after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Recovery quality scores at 48 hours and 7 days after surgery;Preoperative anxiety;Intraoperative and postoperative 24 - hour opioid consumption;The incidence and score of postoperative sleep disorders;Postoperative emergence agitation;Patient satisfaction at 24 hours postoperatively;The incidence rates of hypotension, bradycardia, and hypoxia from the time of medication administration to 24 hours postoperatively;The incidence of nausea, vomiting, and dry mouth at 24 hours postoperatively; | — |
Countries
China
Contacts
Public ContactWencai Jiang
Deyang People's Hospital
Outcome results
None listed