bacterial vaginosis (BV)
Conditions
Interventions
Healthy Controls:Healthy control group, women with normal medical examination
Antibiotic therapys:Conventional antibiotic treatment group, metronidazole vaginal suppository, vaginal application 1 time/day* 7 days
Probiotic interventions:Probiotic treatment group, vaginal probiotic treatment, use as directed* for 7 days
Probiotics + antibiotic therapys:In the probiotic + antibiotic treatment group, antibiotic treatment was followed by 12 hours of combined probiotic treatment for 7 days
Sponsors
The Ninth Hospital of Nanchang
Eligibility
Sex/Gender
Female
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: 1. Age between 18-55 years, history of sexual intercourse, meeting the diagnostic criteria for BV; 2. No malignant tumour of the reproductive tract, excluding CIN3, no history of hysterectomy and pelvic radiotherapy; 3. No antimicrobial treatment within 3 months, no sexual intercourse for 3 days before the examination, no vaginal douching and no medication.
Exclusion criteria
Exclusion criteria: 1. Patients with gonorrhea, genital herpes, and genital warts; 2. Individuals with reproductive system and other systemic diseases; 3. Pregnancy; 4. Breastfeeding women; Patients who have undergone vaginal flushing, used spermicides, and sanitary tampons within 7 days prior to treatment. 6. Abnormal HPV and TCT testing; 7. Use systemic medications; 8. Use probiotics (orally or vaginally); 9. Use traditional Chinese medicine or homeopathic medicine; 10. Acute diseases; 11. History of tumor; 12. Positive serological tests for HIV, hepatitis C, hepatitis B, or syphilis. 13. History of gastrointestinal diseases, autoimmune diseases and immunomodulatory therapy, chronic pain and neuropsychiatric disorders, obesity (BMI>30).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical outcomes after treatment; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pathogenetic efficacy after treatment;Changes in vaginal flora after treatment; | — |
Countries
China
Contacts
Public ContactXia He
The Ninth Hospital of Nanchang
Outcome results
None listed