thyroid gland
Conditions
Interventions
dexmedetomidine group:Group D received dexmedetomidine nebulization (1 µg/kg) 15 minutes before surgery, and drug solutions were diluted to 4 mL by adding normal saline.
budesonide group:Group B received budesonide nebulization (2mg) 15 minutes before surgery.
Sponsors
The First Affiliated Hospital of Shihezi University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Age between 18 and 65 years; 2. Patients scheduled for elective thyroid surgery under General Anaesthesia (GA) with endotracheal intubation; 3.American Society of Anesthesiologists (ASA) physical status I to II. No contraindications such as severe cardiopulmonary insufficiency and liver and kidney function impairment; 4.Body mass index (BMI) <40kg/m^2; 5.Patients understand the use of the scale and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Allergic to dexmedetomidine or budesonide; 2.Use pain relievers, such as nonsteroidal anti-inflammatory drugs or opioids or steroids before surgery; 3.Have not quit smoking; 4.Patients with a history of pre-operative sore throat, hoarseness, cough, upper respiratory tract infection, pregnancy, chronic obstructive pulmonary disease or Mallampati grade >II; 5.Patients with a history of gastroesophageal reflux disease or cervical injury.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative sore throat during the first 24h after extubation; | — |
Secondary
| Measure | Time frame |
|---|---|
| VAS score of postoperative sore throat during the first 24h after extubation;Perioperative hemodynamic parameters;Incidence of cough and hoarseness during the first 24h after extubation;Severity of cough and hoarseness during the first 24h after extubation;Medication related indicators;Postoperative analgesic drug dosage; | — |
Countries
China
Contacts
Public ContactWei Tao
The First Affiliated Hospital of Shihezi University
Outcome results
None listed