depression
Conditions
Interventions
Positive Control Group (ECT Group):The ECT treatment received by patients in this group is the standard treatment method of the Department of Psychiatry at the First Affiliated Hospital of Chongqing M
The Experimental Treatment Group (tACS Group) :The Nexalin ADI device is used, with electrode placement at F1, F2, FZ (frontal regions), and both mastoids. The treatment involves applying an alternati
Sponsors
The First Affiliated Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Age
12 Years to 17 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged 13-17 years old who visit our hospital's outpatient department; 2. MDD diagnosis is made according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), and assessed by at least one professional psychiatrist; 3. Meet the criteria of a score of =25 on the Hamilton Depression Rating Scale; 4. Have not previously undergone physical treatments such as electroconvulsive therapy, alternating current, or direct current; 5. Are able to understand the content of the questionnaire and answer truthfully; 6. Voluntarily participate in this project and have a guardian sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients with comorbid mental disorders; 2. Patients with relative contraindications to ECT or neuromodulation treatments (such as having severe physical diseases, intracranial hypertension, severe infection and fever, taking reserpine-containing drugs, being allergic to anesthetic muscle relaxants, having other risk factors for general anesthesia, etc.); 3. Patients with substance abuse or dependence; 4. Patients with impaired skin integrity at the electrode placement site; 5. Patients with implanted electronic devices; 6. Patients who are uncooperative and unable to complete assessments/who refuse to complete the 12-week clinical follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton Depression Scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hamilton Anxiety Scale;Beck Suicide Intention Scale;Self Rating Depression Symptom Scale;Generalized Anxiety Disorder Scale;Pittsburgh sleep quality index;Perceived Deficits Questionnaire – Depression;International Physical Activity Questionnaires - Short Form;Clinical Global Impressions;functional near- infrared spectroscopy;functional magnetic resonance imaging, fMRI;event-related potential of EEG; | — |
Countries
China
Contacts
Public ContactLi Kuang
The First Affiliated Hospital of Chongqing Medical University
Outcome results
None listed