Non-suicidal self-injury in adolescents
Conditions
Interventions
Self-injury group with diagnosis:rTMS
control group:N/A
Self-injury group without diagnosis:rTMS
Sponsors
Chengdu Brain Science Research Institute of University of Electronic Science and Technology of China/The Fourth People’s Hospital of Chengdu
Eligibility
Sex/Gender
All
Age
12 Years to 18 Years
Inclusion criteria
Inclusion criteria: Test group (N=160) 1.Aged 12~18, Han nationality, right-handed; 2.Understand the purpose and process of this study and voluntarily participate in this experiment; 3.Whether to join the group or not is judged by the results of NSSI Behavior and Function Scale and the results of its Impulse Assessment Scale (the number of self-injury behaviors with non-suicidal intention should be no less than 5 times within one year, and the number of self-injury behaviors within two weeks before joining the group should be no less than zero; In addition, the Barratt impulsiveness scale should have a score >=72, and those with a score < 72 according to the literature are individuals with low impulsiveness (Stanford, M.S., Mathias, C.W., Dougherty, D.M., Lake, S.L., Anderson, N.E., & Patton, J. H. (2009). Fifty years of the Barratt Impulsiveness Scale: An update and review. Personality and Individual Differences, 47(5), 385–395.); 4. Never received rTMS treatment or electroconvulsive therapy in the last 6 months; 5.Never used any antipsychotic drugs or antidepressants within 4 weeks before joining the group. Because it is necessary to distinguish the influence of disease factors on the experimental results, it is necessary to distinguish NSSI patients with psychiatric diagnosis (N=80) from NSSI patients who have not reached any psychiatric diagnosis (N=80) in subgroup analysis. Therefore, the disease diagnosis of the former must meet the following conditions before being included in the accompanied diagnosis group: The diagnostic interview for mental disorders in children and adolescents (Kinder-dips) was used by two attending and above psychiatrists, and the diagnosis was in line with the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (The Diag) Diagnostic criteria of depressive disorder in the diagnostic and statistical manual of mental disorders fifth edition (DSM-V). And they receive corresponding drug treatment during the treatment period, and the drug range is fluoxetine or sertraline approved by FDA for the treatment of adolescent depression. The disease-free diagnosis group not only meets the basic conditions of the test group, but also meets the following conditions: By using Kinder-DIPS diagnostic program by two attending and above psychiatrists, no one in DSM-V can be diagnosed. And he did not receive any psychiatric medication during the whole study period. Healthy control group (N=40) 1.Aged 12~18, Han nationality, right-handed; 2.Understand the purpose and process of this study and voluntarily participate in this experiment; 3.The diagnosis of DSM-V can't be achieved by two attending psychiatrists with Kinder-DIPS diagnostic program; 4.No NSSI, suicidal behavior and family history of mental illness; 5.Never received rTMS treatment or electroconvulsive therapy; 6.Never used any antipsychotic drugs or antidepressants;
Exclusion criteria
Exclusion criteria: 1. Have a history of brain organic diseases, serious physical diseases, craniocerebral trauma or injury; 2.Other neurological and mental diseases such as neurodevelopmental disorder, schizophrenia pedigree and neurocognitive disorder; 3.Have a history of alcohol or substance abuse and drug abuse;4. Do not have the ability of independent reading and writing; 5. Received rTMS or electroconvulsive therapy before; 6. Those who have received any form of psychotherapy in the past three months; 7. There was a history of attempted suicide in the past year; 8. Had a seizure.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| NSSI behaviour;impulsivity;HbO; | — |
Countries
China
Contacts
Public ContactDu Na
Chengdu Brain Science Research Institute of University of Electronic Science and Technology of China/The Fourth People’s Hospital of Chengdu
Outcome results
None listed