Nonparoxysmal atrial fibrillation
Conditions
Interventions
Intervention group:48 hours before RF ablation:
Amiodarone was administered for 48 hours
Amiodarone is taken orally 200mg po tid
From 3 months after radiofrequency ablation:
Amiodarone 200mg tid taken
Control group:48 hours before RF ablation:
Do not use any antiarrhythmic drugs other than beta blockers, if used, discontinue the drug for at least 5 half-lives
Up to 3 months after surgery:
Amiodaro
Sponsors
The First Affiliated Hospital of Nanjing Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged between 18 and 80; 2. Persistent atrial fibrillation; 3. No history of atrial fibrillation/ablation; 4. No contraindications for radiofrequency ablation.
Exclusion criteria
Exclusion criteria: 1.EF 280ms; 5.LAD > 50mm. 6. Left atrial or left auricular thrombus; 7. Use other antiarrhythmic drugs in combination; 8. Severe liver or kidney damage (ALT=3ULN or eGFR<30 ml/min/1.73m2) 9. Abnormal thyroid function; 10. History of iodine allergy; 11. History of diffuse pulmonary interstitial fibrosis; 12. Patients with severe hypotension; 13. Pregnancy and lactation; 14. Reluctance to continue current medication during the study period; 15. Life expectancy is less than 12 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Acute atrial arrhythmia events in the blank period after ablation; | — |
Secondary
| Measure | Time frame |
|---|---|
| The quality of life of the patient in the first month and the third month after the operation;Intraoperative non-pulmonary vein trigger foci, atrial fibrillation termination methods and concurrent other arrhythmias;The recurrence rate of atrial arrhythmias within one year after surgery;Amiodarone-related side effect events; | — |
Countries
China
Contacts
Public ContactWang Zidun
The First Affiliated Hospital of Nanjing Medical University
Outcome results
None listed