Infertility
Conditions
Interventions
morphological group:Embryo morphology was scored and embryos were selected for transfer.
miRNA group:The miRNA gene expression profile of cumulus cells was detected to select the embryo for transfer.
Sponsors
The First Affiliated Hospital of Wenzhou Medical University
Eligibility
Sex/Gender
Female
Age
22 Years to 37 Years
Inclusion criteria
Inclusion criteria: 1) Age 22-38 years old (excluding 38 years old, calculated as the date of signing ICF during the screening period minus the birthday of the subject); 2) Normal ovarian reserve with bilateral AFC>=6 and AMH of 1.4-5.0ng/ml; 3) Menstrual cycle: 21-35 days (including boundary value); 4) Using an antagonist protocol and recombinant FSH as gonadotropin; 5) Fertilization by IVF; 6) =8; 8) D3 high-quality embryos >=2; 9) Consent for elective D3 fresh single embryo transfer; 10) Subjects voluntarily signed ICF; 11) The first fresh or first frozen-thawed transfer cycle of each subject.
Exclusion criteria
Exclusion criteria: 1) Patients with recurrent miscarriage (>=2 previous miscarriages); 2) Polycystic ovary syndrome (PCOS) diagnosed according to the Rotterdam criteria; 3) Patients with uterine fibroids (submucosal fibroids >3cm or intramural fibroids affecting uterine cavity shape), untreated endometrial polyps, endometrial hyperplasia, intrauterine adhesions, uterine malformations, ASRM stage III-IV endometriosis, and hydrosalpinx that may affect the clinical outcome of transplantation; 4) Mate with severe oligospermia and asthenospermia (sperm concentration 30% or obstructive azoospermia (donor sperm could not be excluded for these criteria); 5) Chromosomal abnormalities in men or women, except for polymorphism; 6) Other conditions that are not suitable for conventional IVF treatment according to clinical routine; 7) Those who were deemed unsuitable for the study by the investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical pregnancy rate per transfer; | — |
Secondary
| Measure | Time frame |
|---|---|
| Live birth rate per transfer;Ongoing pregnancy rate per transfer;Miscarriage rate; | — |
Countries
China
Contacts
Public ContactXuefeng Huang
The First Affiliated Hospital of Wenzhou Medical University
Outcome results
None listed