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Preoperative study of the correlation between BDNF-TrkB signaling pathway expression levels in cerebrospinal fluid and blood and postpartum depression

Preoperative study of the correlation between BDNF-TrkB signaling pathway expression levels in cerebrospinal fluid and blood and postpartum depression

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500097358
Enrollment
Unknown
Registered
2025-02-18
Start date
2024-09-08
Completion date
Unknown
Last updated
2025-02-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

The diagnosis of postpartum depression (PPD)

Interventions

Observation group:None

Sponsors

The First People’s Hospital of Lianyungang
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
20 Years to 35 Years

Inclusion criteria

Inclusion criteria: 1. Meet the indications for cesarean section and have no contraindications to neuraxial anesthesia; 2. 20 years old<= age <= 35 years old; 3. 37<= gestational age< 42; 4. American Society of Anesthesiologists (ASA) grade II~III; 5.singleton pregnancy; 6.Voluntarily participate in this study and sign the informed consent form.

Exclusion criteria

Exclusion criteria: 1. Unable to understand the content of the questionnaire correctly; 2. a clear history of mental illness, depression, cognitive impairment and other diseases; 3. Patients who have been taking sedative, analgesic and psychotropic drugs for a long time; 4. Those who have recently used glucocorticoids or immunosuppressants; 5. Those who are allergic to or have contraindications to any of the drugs used in this study; 6. Serious pregnancy complications, such as preeclampsia, placental hyperplasia, etc; 7. Participated in other clinical studies within the last 3 months.

Design outcomes

Primary

MeasureTime frame
BDNF(proBDNF?mBDNF);

Secondary

MeasureTime frame
TrkB;p-CREB;Albumin;

Countries

China

Contacts

Public ContactXiaobao Zhang

The First People’s Hospital of Lianyungang

hotdog100@163.com+86 189 6132 2507

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026