Severe pancreatitis
Conditions
Interventions
Control Group:Fasting, anti-infection, replenishing blood volume, inhibiting gastric acid secretion, gastrointestinal decompression, maintaining water and electrolyte balance
Group A:Fasting, anti-infection, blood volume supplementation, inhibition of gastric acid secretion, gastrointestinal decompression, maintenance of water and electrolyte balance +0.1mg/kg*h injection
Group B:Fasting, anti-infection, blood volume supplementation, inhibition of gastric acid secretion, gastrointestinal decompression, maintenance of water and electrolyte balance +0.2mg/kg*h Injection
Sponsors
Dazhou Central Hospital
Eligibility
Sex/Gender
All
Age
20 Years to 65 Years
Inclusion criteria
Inclusion criteria: Meets the diagnostic criteria for acute pancreatitis in the Chinese Guidelines for the Diagnosis and Treatment of Acute Pancreatitis (2021) (with the following 2 or more points): a. persistent upper abdominal pain, b. serum amylase and/or lipase concentration at least 3 times higher than the upper limit of normal, c. abdominal imaging examination results show imaging changes consistent with acute pancreatitis; Admitted within 24 hours of onset; Age range from 20 to 65 years old; All patients have given informed consent and voluntarily joined this study, and have been approved by the hospital ethics committee; Complies with the indications for Sivelestat Sodium.
Exclusion criteria
Exclusion criteria: Other intestinal diseases, pregnancy or lactation, malignant tumor, Coagulopathy and hemorrhagic disease, intestinal surgery and intestinal adhesion Poor compliance or incomplete clinical data, accompanied by communication disorders and mental illness.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| TNF-a;IL-6;IL-10; | — |
Secondary
| Measure | Time frame |
|---|---|
| CRP;IL-1ß;CD4+;CD8+;CD4+/CD8+; | — |
Countries
China
Contacts
Public ContactWenlai Zhou
Dazhou Central Hospital
Outcome results
None listed