Parkinson's disease
Conditions
Interventions
Gold Standard:Primary PD patients who meet the diagnostic criteria of Parkinson's disease formulated by the British Parkinson Society Brain Bank [1]
b. age <80 years old
c. Mini-Mental State Examination =24
d. History of head injury and psychiatric history were excluded.
Index test:The content of p-a-synuclein protein in hair follicles
Sponsors
Renmin Hospital of Wuhan University
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Primary PD patients who meet the diagnostic criteria of Parkinson's disease formulated by the British Parkinson Society Brain Bank [1]; 1.b. age <80 years old; 2.c. Mini-Mental State Examination =24; 3.d. History of head injury and psychiatric history were excluded. 2. The diagnosis of MSA patients was in accordance with the corresponding diagnostic criteria in the Second International Expert Consensus on Diagnosis in 2008 [2] and the Chinese Expert Consensus on Diagnostic Criteria for MSA in 2017 [3]. 3. The diagnosis of DLB patients was in accordance with the relevant diagnostic criteria of DLB International Research Collaboration Group "Diagnosis and treatment of Dementia with Lewy bodies: the Fourth Consensus Report of DLB Consortium" [4] in 2017. (4) The normal controls had no known psychiatric or neurological diseases, and had no complaints of movement disorder, memory disorder, or cognitive decline. 5. Informed consent was obtained from all subjects. 6. The subjects promised to abide by the research procedures and cooperate with the implementation of the whole process of the study.
Exclusion criteria
Exclusion criteria: 1.a. Complicated with cerebrovascular disease, epilepsy, cerebral hemorrhage, intracranial infection and other nervous system diseases, with a history of brain trauma; 2.b. Combined with severe primary diseases of the liver, kidney, hematopoietic system, or abnormal liver function, AST and ALT greater than 1.5 times of the normal value, creatinine greater than the upper limit of the normal value; 3.c. cancer in the past 10 years; 4.d. Persons with a history of substance, drug or alcohol abuse; 5.e. mental and behavioral abnormalities; 6.f. Inability to complete the follow-up examination; 7.g. Inability to cooperate with specimen collection;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The content of p-a-synuclein protein in hair follicles;Accuracy;Sensitivity;Specificity; | — |
Secondary
| Measure | Time frame |
|---|---|
| evaluation of cognitive function;Unified Parkinson's Disease Rating Scale;Positive predicative value;Negative predictive value; | — |
Countries
China
Contacts
Public ContactZhentao Zhang
Renmin Hospital of Wuhan University
Outcome results
None listed