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The Effect of Crystalloid and Colloid Coload Combined with Prophylactic Norepinephrine Infusion for Preventing Post-spinal Anesthesia Hypotension on Neonatal Outcome during Cesarean Section

The Effect of Crystalloid and Colloid Coload Combined with Prophylactic Norepinephrine Infusion for Preventing Post-spinal Anesthesia Hypotension on Neonatal Outcome during Cesarean Section: A prospective, randomized, controlled trial

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500097324
Enrollment
Unknown
Registered
2025-02-17
Start date
2025-03-01
Completion date
Unknown
Last updated
2025-02-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postspinal Anesthesia Hypotension

Interventions

Control group:Spinal anesthesia was immediately applied without Coload and a continuous intravenous infusion of 0.05 ug/kg/minute norepinephrine was given
Crystalloid group:10 ml/kg crystalloid coload after spiSpinal anesthesia was immediately applied without Coload and a continuous intravenous infusion of 0.05 ug/kg/minute norepinephrine was given ...n
Colloid group:10 ml/kg colloid coload after spSpinal anesthesia was immediately applied without Coload and a continuous intravenous infusion of 0.05 ug/kg/minute norepinephrine was giveninal anesthesi

Sponsors

General Hospital of Ningxia Medical University
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 40 Years

Inclusion criteria

Inclusion criteria: 1. Singleton full-term pregnancies aged 18-40 years old (including primiparous and multiparous women) undergoing cesarean section under combined spinal-epidural anesthesia; 2. ASA Grading II

Exclusion criteria

Exclusion criteria: 1. Height 100kg or BMI>=40kg/m2; 3. Eclampsia or chronic hypertension or basal systolic blood pressure >=160mmHg; 4. Hemoglobin<7g/dl; 5. Fetal distress or known abnormal fetal development

Design outcomes

Primary

MeasureTime frame
Umbilical artery pH;Umbilical artery BE;

Secondary

MeasureTime frame
Incidence of maternal adverse events;Apgar scores;Number of norepinephrine interventions;General information (age; Height; Weight; BMI);Basic vital signs (systolic blood pressure, heart rate);Anesthesia plane;Anesthesia until delivery of the fetus;Days of postoperative hospital stay;

Countries

China

Contacts

Public ContactYi Chen

General Hospital of Ningxia Medical University

czzyxgp@163.com+86 182 9518 4600

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026