Premature Ovarian Insufficiency
Conditions
Interventions
treatment group:Local single injection of human umbilical cord mesenchymal stem cell apoptotic vesicles (MSC-apoVs) on both ovaries
Sponsors
The Second People’s Hospital of Foshan
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1.Age >=18 years old; 2.Patients with newly diagnosed POI who refused hormone replacement and voluntarily chose to participate in this study; 3.Patients who have been diagnosed with POI and have poor clinical treatment effect; 4.Sign the subject's informed consent.
Exclusion criteria
Exclusion criteria: 1.There are genetic factors associated with ovarian reserve deficiency (Turner syndrome, chromosome abnormalities, etc.); 2.untreated submucous fibroids, untreated endometrial polyps, uterine adhesions, untreated pathological ovarian cysts, and previous ovaria-related surgical history; 3.Patients with severe or unstable cardiovascular, respiratory, liver, kidney, blood, endocrine, central nervous system, immune dysfunction and malignant tumor diseases; 4.Acute and chronic pelvic inflammation and suspected pelvic adhesion; 5.Patients with relevant hormone replacement therapy 3 months before screening; 6.Hepatitis B, hepatitis C activity period; 7.Patients who have been diagnosed with hyperthyroidism or hypothyroidism within one year before screening and are still taking medication; 8.Those who have plans to have a second child or plan to get pregnant in the near future; 9.The investigator believes that the subjects have other conditions that are not suitable for participation in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Safety evaluation index; | — |
Secondary
| Measure | Time frame |
|---|---|
| Effectiveness evaluation index; | — |
Countries
China
Contacts
Public ContactDong Julang
The Second People’s Hospital of Foshan
Outcome results
None listed