The Median Effective Dose and studies on Pharmacokinetics of Afentanil combined with Remimazolam Tosilate for hysteroscopic Surgery
Conditions
Interventions
Patients undergoing hysteroscopic surgery:If the patient has a reaction such as body movement affecting the examination operation during the hysteroscopic diagnosis and treatment operation, and each b
Sponsors
Qingdao Women and Children's hospital
Eligibility
Sex/Gender
All
Age
20 Years to 60 Years
Inclusion criteria
Inclusion criteria: Operation time < 30min; b) Patients who can tolerate anesthesia and hysteroscopy; c) ASA grades I ~ II; d) Age 20-60 years old; e) body mass index (BMI) 18-25 kg/m^2; f) No recent use of benzodiazepines, opioids, no history of narcotic drug dependence; g) Before the trial, patients should have a detailed understanding of the nature, significance, possible benefits, possible inconveniences and potential dangers of the trial, understand the study procedure and sign the informed consent in person.
Exclusion criteria
Exclusion criteria: a) Patients with severe heart, brain, lung, kidney and other vital organ dysfunction; b) Patients with neurological diseases, cognitive dysfunction and mental disorders; c) Allergic to benzodiazepines, opioids, propofol and other drugs used in this study; d) Patients with recent acute respiratory inflammation and no cure history; e) Long-term use of analgesic and sedative drugs, suspected drug abuse, narcotic sedative and analgesic drugs; f) Preoperative BBP > 180mmHg and/or diastolic blood pressure > 110mmHg.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intraoperative body movements; | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in heart rate, mean arterial pressure, oxygen saturation, respiratory rate;Time to induction of anesthesia;Duration of surgery;Anesthesia recovery time;Occurrence of adverse reactions;Pain 30 minutes after surgery;Postoperative nausea and vomiting;Postoperative patient satisfaction;General condition of the patient; | — |
Countries
China
Contacts
Public ContactLiang Yongxin
Department of Anesthesiology, Qingdao Women and Children's hospital
Outcome results
None listed