Trauma
Conditions
Interventions
Trauma Group:Trauma caused by accidental injury
Control Group:Recruited healthy volunteers
Sponsors
Shenzhen People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Age Limitations: Participants must be over 18 years old to ensure that the study subjects have a mature immune system and stable physiological state. 2.Trauma Type: Participants must have sustained trauma due to accidental injuries, including traffic accidents, falls, sports injuries, etc., to ensure homogeneity within the study population. 3.Treatment Requirement: Participants must require hospitalization due to the severity of their trauma, ensuring that the study focuses on trauma patients who need medical intervention. 4.Admission Time: Participants must be admitted within 24 hours after trauma to minimize the impact of delayed post-traumatic time on complement level measurements.
Exclusion criteria
Exclusion criteria: 1.Severely Impaired Immune Function: Exclude patients with hematological diseases, HIV, tumors, or other conditions causing severe immune dysfunction, as these conditions may affect complement system activity. 2.Medication Effects: Exclude patients who have been taking medications that impact immune function, such as corticosteroids or immunosuppressants, to avoid interference with complement levels. 3.Special Physiological States: Exclude lactating or pregnant women, as hormonal changes and the presence of the fetus may affect the complement system. 4.Treatment Willingness: Exclude patients who refuse treatment to ensure that all participants receive standard trauma care and necessary medical interventions. 5.Comorbidity Restrictions: Exclude patients with severe cardiac, pulmonary, hepatic, or renal dysfunction, as these comorbidities may affect complement system activity and trauma prognosis. 6.Previous Surgery History: Exclude patients who have undergone major surgery within the past 6 months to reduce the potential impact of surgery on complement levels and trauma prognosis. 7.Infection Status: Exclude patients with active infections at the time of admission, as infections may activate the complement system and affect the interpretation of study results. 8.Drug Allergy History: Record any history of drug allergies (especially to drugs that may be used in the study) to avoid severe allergic reactions during the research. 9.Lifestyle Factors: Record smoking and drinking habits, as these factors may affect immune function and the trauma healing process. 10.Psychological Status: Assess the patient's mental health status and exclude individuals with severe psychological disorders or cognitive impairments, as these conditions may affect the patient’s cooperation and the accuracy of study results.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Complement C1q, Bb, MBL, C3b, C3a, C5a, sC5b-9, tissue factor, thrombin, and CD59; | — |
Secondary
| Measure | Time frame |
|---|---|
| IL-6,TNF-a; | — |
Countries
China
Contacts
Public ContactShanshan Mei
Shenzhen People's Hospital
Outcome results
None listed