Amblyopia
Conditions
Interventions
Experimental group:2 hours of patching combined with atropine daily
Control group:6 hours of patching daily
Sponsors
Eye & ENT Hospital, Fudan University
Eligibility
Sex/Gender
All
Age
3 Years to 8 Years
Inclusion criteria
Inclusion criteria: 1. Age: 3-8 years old; 2. Wear glasses for at least 4 weeks before enrollment (refractive correction alone can obtain different degrees of visual acuity improvement, and too short wearing time may be mixed with refractive correction factors when evaluating the treatment effect, but the latest research found early.) Covering can obtain a better treatment effect, so the time of wearing glasses before enrollment is 4 weeks; 3. BCVA=2 rows; 4. Strabismus, anisometropia or mixed amblyopia: 5. Diagnostic criteria for strabismus: strabismus in distant or near vision with or without glasses, or history of previous strabismus surgery; 6. Diagnostic criteria for anisometropia: binocular spherical equivalence (SE) difference >=1.00D, or astigmatism difference >=1.50D; 7. Mixing: the above two situations exist at the same time; 8. Except for refractive correction and strabismus surgery, have not received other amblyopia treatment; 9. The subject's parents or legal guardians have signed the informed consent form and are willing to undergo randomization and regular follow-up.
Exclusion criteria
Exclusion criteria: 1. Myopia; 2. In addition to strabismus and anisometropia, there are other eye diseases that affect vision; 3. History of intraocular surgery; 4. Allergy to atropine or other cycloplegic agents; 5. Presence of contraindications to atropine; 6. Down syndrome or obvious developmental delay and inability to cooperate with the examination; 7. Birth < 34 weeks or birth weight < 1500 grams; 8. Participate in other clinical studies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Best corrected visual acuity of the amblyopic eye; | — |
Secondary
| Measure | Time frame |
|---|---|
| Stereoacuity; | — |
Countries
China
Contacts
Public ContactYao Jing, Zhao Chen
Eye & ENT Hospital, Fudan University
Outcome results
None listed